Immunogenetics of autoimmune diseases
Our main research focus is to identify and functionally characterize genetic factors that predispose to type 1 diabetes and other autoimmune diseases. The genetic risk factors have to a large extent been connected to gene expression and gene regulation of immune cells. To get a deeper understanding of such aspects, we are studying different layers of genomic information; e.g. transcriptome, methylation and microRNA across a wide specter of immune cells both from blood and thymus. These regulatory profiles are investigated against autoimmune genetic risk loci (revealed through genome-wide association studies), and analysed against response to treatment.
Some of our projects:
1. Characterization of the transcriptome of various immune cells in thymus and profiling of expression of tissue restricted autoantigens.
2. Exploring genetic, epigenetic and environmental risk factors, and their interactions, in rheumatoid arthritis, an autoimmune disease sharing many risk factors with type 1 diabetes.
3. Epigenetic profiling of immune cells from rheumatoid arthritis patients and their correlation with treatment response.
4. Quantification of the expression levels of HLA alleles, the main genetic determinant for autoimmune diseases, on different immune cells from thymus and blood.
Benedicte A. Lie, Professor
Marte K. Viken, postdoc
Mario Saare, postdoc (01.04.2019)
Fatemeh Kaveh, postdoc (until 01.02.2018)
Ingvild Gabrielsen, PhD student (until 18.03.2019)
Kari Guderud, PhD student
Line Sunde, PhD student
Fatima Heinicke, PhD student
Maria Dehli Vigeland, PhD student
Asgeir Lande, PhD student
Riad Hajdarevic, PhD student
Marte Heimli, PhD student (from 01.02.2019)
Sofie Andersen, Master student
Anne Rydland, Medical Laboratory Scientist
Siri Flåm, Medical Laboratory Scientist