Anna Dis Margeirsdottir
Position: MD, Pediatric endocrinologist. Post doc
Place of work:Unit Endocrinology and Diabetes, Department of Paediatrics, Oslo University Hospital Ullevål
Phone: +47 22118765
Current research focus
Childhood onset diabetes and early cardiovascular disease
Strategy: To examine in long term prospective studies the development of microvascular complications and early stages of atherosclerosis in children, adolescents and young adults with type 1 diabetes. To define predictive factors and pathogenetic mechanisms, i.e. advanced glycation of proteins, inflammation and lipid disturbances. To develop better strategies for prevention of these complications. To develop better strategies for improvement of blood glucose control and clinical outcomes in childhood onset diabetes.
Atherosclerosis and Childhood Diabetes.
Summary of the project:
Introduction: Type-1 diabetic patients are at increased risk (x4) of premature and extensive atherosclerosis and cardiovascular disease (CVD). Atherosclerosis starts in childhood and adolescence and it starts even earlier and is more severe in persons with type-1 diabetes than in non-diabetic subjects.
Aim: To evaluate early stages of atherosclerosis, the progression of atherosclerosis and which risk factors predicate the development of atherosclerosis in patients with childhood onset type-1 diabetes, and to compare the findings with no diabetic control subjects.
Subjects: All children and adolescents with diabetes, aged 8-18 years in eastern part of Norway were invited to participate in the study (n=800). 314 patients (39%) participate. 120 age-matched healthy controls were also included.
Design: Population based study. Prospective clinical study with examinations every 5th year.
Methods: Clinical data: height, weight, puberty stages, waist circumference, blood pressure and tobacco smoking. Family history of CVD and diabetes in first and second degree relatives. Four days registration of dietary intake and standardized questionnaires of physical activity.
Clinical chemistry: HbA1c, lipids, coagulation/fibrinolysis, markers of inflammation. Four different AGEs (Advanced Glycation Endproducts) will be measured: “total” serum AGE, CML, hydroimidalazone and glucosepane (so far never examined in children).
IMTs in common carotid artery and vessel stiffness by pulse wave reflection measured by high performance ultrasound. Myocardial function by Echocardiogram. When patients are >18years of age, advanced cardiac imaging will be requested in the follow-up studies
The data analysis is not yet completed.
Norwegian Childhood Diabetes and Quality project (NCDQ)- a nationwide prospective population-based study for research and quality improvement by means of benchmarking. Part of the Norwegian Quality Register for Childhood and Adolescent Diabetes.
Advanced glycation of proteins and vascular complications in childhood diabetes.
Dietary intake, meal pattern and physical activity in children and adolescents with type 1 diabetes
Childhood diabetes and celiac disease – a population based study