Lars Chr Stene – new publication in Diabetes

Reseacher in Oslo Diabetes Research Centre and Norwegian Institute of Public Health (NIPH) Lars Chr. Stene has an important paper in the last issue of DIABETES, the best journal in the field of diabetes (1).

Congratulations Lars Christian !

– What did you find Lars Christian ?

We found that children who had enterovirus in their blood (RNA) had greater risk of converting from just antibodies towards beta cells to clinical type 1 diabetes.

– What does this mean ?

It may signify that virus infection is not the cause of type 1 diabetes in itself  , but may hasten the conversion from just having the antibody  to contract the disease.

– How did you perform the study ?

I have utilized the DAISY (Diabetes and Autoimmunity Study in the Young) study which sampled blood and stool annually from children from  newborn age until   about 15 years. We selected the newborn at increased risk for type 1 Diabetes  by HLA typing.

– How did you get access to such an important study ?

I worked one year at Barbara Davis Center for Childhood Diabetes i Denver, USA

We made the plan for the study already in 2004 so I am happy to see the paper now !

–  It is a long time since you stayed in Denver, but you still have an active collaboration ?

Yes, such a stay is stimulating one’s research also in the long term. You get to know collaborating  partners whom you  will share ideas and projects with for years to come. I will recommend everyone to have a study period abroad.

– What do you plan to do next with this particular  project ?

We will investigate if there are special characteristics of the enterovirus leading to type 1 diabetes. Enterovirus is a broad group of virus and  the sequence of the particular RNA is highly interesting and may lead to the culprit for type1 diabetes

– Best luck with your future research , Lars Christian !

Thank you !

  1. Stene LC, Oikarinen S, Hyöty H, Barriga KJ, Norris JM, Klingensmith G, Hutton JC, Erlich HA, Eisenbarth GS, Rewers M.Enterovirus infection and progression from islet autoimmunity to type 1 diabetes: the Diabetes and Autoimmunity Study in the Young (DAISY).Diabetes. 2010 ;59:3174-80.